This selection highlights publications documenting the research and development journey behind PETsys technology. Authored by PETsys team together with academic and institutional partners, these works trace the evolution and maturation of our solutions, spanning ASIC development, detector innovation, and system-level advances in medical imaging and high-energy physics.

• Experimental characterization of the TOFPET2 ASIC
  R. Bugalho, A. Di Francesco, L. Ferramacho, C. Leong, T. Niknejad, L. Oliveira, M. Rolo, J.C. Silva, R. Silva, M. Silveira, S. Tavernier, J. Varela
  Journal of Instrumentation. 14, 2019, P03029

• Experimental results with TOFPET2 ASIC for time-of-flight applications
  Ricardo Bugalho, Agostino Di Francesco, Luis Ferramacho, Carlos Leong, Tahereh Niknejad, Luis Oliveira, Luca Pacher, Manuel Rolo, Angelo Rivetti, Miguel Silveira, Jose C. Silva, Rui Silva, Stefaan Tavernier, João Varela
  Nuclear Instruments and Methods, 912, 21 December 2018, Pages 195-198

• TOFPET2: a high-performance ASIC for time and amplitude measurements of SiPM signals in time-of-flight applications
  A. Di Francesco, R. Bugalho, L. Oliveira, L. Pacher, A. Rivetti, M. Rolo, J.C. Silva, R. Silva, and J. Varela
  Journal of Instrumentation, Volume 11, March 2016

• Efficient and cost effective “sum of rows and columns” readout for large numbers of SiPM arrays
  S.P. Tavernier, E. Albuquerque, R. Bugalho, T. Coutinho, L. Ferramacho, R. Francisco, C. Leong, N. Oliveira, M. Silveira, R. Silva, J. Varela
  in: 2024 IEEE Nuclear Science Symposium (NSS), Medical Imaging Conference (MIC) and Room Temperature Semiconductor Detector Conference (RTSD), 2024: pp. 1–1

• Development of high-resolution detector module with depth of interaction identification for positron emission tomography
  Tahereh Niknejad, Marco Pizzichemi, Gianluca Stringhini, Etiennette Auffray, Ricardo Bugalho, Jose Carlos Rasteiro Da Silvai, Agostino Di Francesco, Luis Ferramacho, Paul Lecoq, Carlos Leong, Marco Paganoni, Manuel Rolo, Rui Silva, Miguel Silveira, Stefaan Tavernier, João Varela, Carlos Zorraquino
  Nuclear Instruments and Method, Volume 845, 11 February 2017, Pages 684-688

• A new method for depth of interaction detrmination in PET detectors
  M. Pizzichemi, G. Stringhini, T. Niknejad, Z. Liu1, P. Lecoq, S. Tavernier, J. Varela, M. Paganoni, E. Auffray
  Physics in Medicine and Biology, March 2016, Volume 61, Number 12

• Development of a high-resolution module for PET scanners
  G. Stringhini, M. Pizzichemi, A. Ghezzi, A. Stojkovic, S. Tavernier, T. Niknejad, João Varela, M. Paganoni and E. Auffray
  Journal of Instrumentation, 12, 2017, C0207

• Validation of a highly integrated SiPM readout system with a TOF-PET demonstrator
  T. Niknejad, S. Setayeshi, S. Tavernier, R. Bugalho, L. Ferramacho, A. Di Francesco, C. Leong, M.D. Rolo, M. Shamshirsaz, J.C. Silva, R. Silva, M. Silveira, C. Zorraquino, J. Varela
  Journal of Instrumentation. 11, 2016, P12003
  
  
• A Full Current-Mode AFE With Dark Noise Suppression Using Differential Leading-Edge Discrimination for the CMS/LHC Timing Detector at CERN
  E. Albuquerque, R. Bugalho, L. Bica Oliveira and J. Varela
  IEEE Transactions on Nuclear Science, June 2025, Volume 72, Number 12
  

• The TOFHIR2 readout ASIC of the CMS MTD Barrel Timing Layer
  T. Niknejad, E. Albuquerque, R. Bugalho, V. Dubceac, L. Ferramacho, H. França, M. Firlej, T. Fiutowski, M. Gallinaro, M. Idzik, J. Moron, L. Oliveira, R. Francisco, J.C. Silva, R. Silva, M. Silveira, K. Swientek, J. Varela
  APS April Meeting Abstracts, 2021: p. G20.007

• TOFHIR2: the readout ASIC of the CMS barrel MIP Timing Detector
  E. Albuquerque, M. Araújo, A. Benaglia, A. Boletti, R. Bugalho, T. Coutinho, F. De Guio, P. Faccioli, L. Ferramacho, M. Firlej, T. Fiutowski, R. Francisco, M. Gallinaro, A. Ghezzi, J. Hollar, M. Idzik, H. Legoinha, N. Leonardo, C. Leong, M.T. Lucchini, M. Malberti, G. Marozzo, G. Da Molin, J. Moron, T. Niknejad, L. Oliveira, N. Oliveira, S. Palluotto, M. Pisano, N. Redaelli, C. Silva, J.C. Silva, R. Silva, M. Silveira, K. Swientek, T. Tabarelli de Fatis, S. Tavernier, J. Varela, V. Varela, S. White, J. Wulff
  Journal of Instrumentation. 19, 2024, P05048

• TOFPET ASIC for PET applications
  M.D. Rolo, R. Bugalho, F. Gonçalves, G. Mazza, A. Rivetti, J.C. Silva, R. Silva, J. Varela
  Journal of Instrumentation 8, 2013, C02050

• Development of ClearPEM-Sonic, a multimodal mammography system for PET and Ultrasound
  G. Cucciati, E. Auffray, R. Bugalho, L. Cao, N. Di Vara, F. Farina, N. Felix, B. Frisch, A. Ghezzi, V. Juhan, D. Jun, P. Lasaygues, P. Lecoq, S. Mensah, O. Mundler, J. Neves, M. Paganoni, J. Peter, M. Pizzichemi, P. Siles, J.C. Silva, R. Silva, S. Tavernier, L. Tessonnier, J. Varela
  Journal of Instrumentation 9, 2014, C03008

• EndoTOFPET-US: a novel multimodal tool for endoscopy and positron emission tomography
  N. Aubry, E. Auffray, F.B. Mimoun, N. Brillouet, R. Bugalho, E. Charbon, O. Charles, D. Cortinovis, P. Courday, A. Cserkaszky, C. Damon, K. Doroud, J.-M. Fischer, G. Fornaro, J.-M. Fourmigue, B. Frisch, B. Fürst, J. Gardiazabal, K. Gadow, E. Garutti, C. Gaston, A. Gil-Ortiz, E. Guedj, T. Harion, P. Jarron, J. Kabadanian, T. Lasser, R. Laugier, P. Lecoq, D. Lombardo, S. Mandai, E. Mas, T. Meyer, O. Mundler, N. Navab, C. Ortigão, M. Paganoni, D. Perrodin, M. Pizzichemi, J.O. Prior, T. Reichl, M. Reinecke, M. Rolo, H.-C. Schultz-Coulon, M. Schwaiger, W. Shen, A. Silenzi, J.C. Silva, R. Silva, I. Somlai Schweiger, R. Stamen, J. Traub, J. Varela, V. Veckalns, V. Vidal, J. Vishwas, T. Wendler, C. Xu, S. Ziegler, M. Zvolsky
  Journal of Instrumentation, 8, 2013, C04002

• EndoTOFPET-US data acquisition system
  R. Bugalho, C. Gaston, M.D. Rolo, J.C. Silva, R. Silva, J. Varela
  Journal of Instrumentation 8, 2013, C02049
  
  
• Detection Sensitivity and Light Collection Studies of an APD-based High Packing-Fraction LYSO:Ce Matrix for PET Applications
  Viesturs Veckalns, Ricardo Bugalho, Rui Silva, Jorge A. Neves, Stefaan Tavernier, Carlos
  Zorraquino, Catarina Ortigão, Manuel Rolo, José C. Silva, João Varela,
  Nucl. Instr. and Methods - A, 732, (2013), page 607-610

• Feasibility and electromagnetic compatibility study of the ClearPEM front-end electronics for simultaneous PET-MR imaging
  J.A. Neves, R. Bugalho, R. Gruetter, A.W. Magill, C. Ortigão, J.C. Silva, R. Silva, J. Varela
  Nuclear Instruments and Methods in Physics Research Section A. 702, 2013, 34–36

Relevant Patents

On SiPM readout (ASIC)

• Portuguese patent application nr. 106650, filed on 19.11.2012
• PCT/PT2013/000067, filed on 18.11.2013
• EPO patent application 13814664.2
• Granted in the US: US 9,513,386 B2, Dec. 6, 2016
• Granted in Japan: 6295265, Feb. 23, 2018

For technology based in APDS - Avalanche Photo Diodes (ClearPEM)

• Portugal / PT103200/ 31-10-2006/ Granted/ PT103200
• PCT/ WO2006049523A3/ 15-02-2007
• USA/ US20080103391A1/ 01-05-2008/ Granted/ US. 7,917,192

On "Scintillator array for gamma ray or X-ray detection with Depth of Interaction information", from work conducted in partnership with CERN

• PT 20141000083247, Oct. 23, 2014
• PCT/EP2015/074462,Oct. 22, 2015
• Granted in the US: US 10,203,419 B2, Feb. 12, 2019 (Detector component for an X-ray or Gamma ray detector)